Mitogenic repression of myogenin autoregulation.

Regulation of the araC gene of Escherichia coli: catabolite repression, autoregulation, and effect on araBAD expression.

The araC gene encodes a positive regulatory protein required for L-arabinose utilization in Escherichia coli. Transcription from the araC promoter has been shown to be under positive control by cAMP receptor protein and under negative control by its protein product (autoregulation). This work describes the identification of the region of the araC promoter that interacts with the cAMP receptor p...

Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR

The Escherichia coli MelR protein is a transcription activator that autoregulates its own promoter by repressing transcription initiation. Optimal repression requires MelR binding to a site that overlaps the melR transcription start point and to upstream sites. In this work, we have investigated the different determinants needed for optimal repression and their spatial requirements. We show tha...

Nuclear localization of MBNL1: splicing-mediated autoregulation and repression of repeat-derived aberrant proteins.

In some neurological diseases caused by repeat expansions such as myotonic dystrophy, the RNA-binding protein muscleblind-like 1 (MBNL1) accumulates in intranuclear inclusions containing mutant repeat RNA. The interaction between MBNL1 and mutant RNA in the nucleus is a key event leading to loss of MBNL function, yet the details of this effect have been elusive. Here, we investigated the mechan...

MyoD and Myogenin

Myogenin Controls Muscle Metabolism

Streptomyces cell death, which occurs as the bacteria develop fruiting bodies and form spores, has been dismissed as nonspecific autolysis caused by cell wall degradation. Now Miguélez et al. (page 515) show that the cell death is complex: it occurs at two different times in two different locations and as a series of defined steps that leave the cell wall intact. Streptomyces grow first along a...